diff --git a/src/economy.cpp b/src/economy.cpp
--- a/src/economy.cpp
+++ b/src/economy.cpp
@@ -1169,9 +1169,10 @@ static void TriggerIndustryProduction(In
 		}
 	} else {
 		for (auto ita = std::begin(i->accepted); ita != std::end(i->accepted); ++ita) {
-			if (ita->waiting == 0) continue;
+			if (ita->waiting == 0 || !IsValidCargoID(ita->cargo)) continue;
 
 			for (auto itp = std::begin(i->produced); itp != std::end(i->produced); ++itp) {
+				if (!IsValidCargoID(itp->cargo)) continue;
 				itp->waiting = ClampTo<uint16_t>(itp->waiting + (ita->waiting * indspec->input_cargo_multiplier[ita - std::begin(i->accepted)][itp - std::begin(i->produced)] / 256));
 			}
 
diff --git a/src/industry_cmd.cpp b/src/industry_cmd.cpp
--- a/src/industry_cmd.cpp
+++ b/src/industry_cmd.cpp
@@ -1122,6 +1122,9 @@ static bool SearchLumberMillTrees(TileIn
  */
 static void ChopLumberMillTrees(Industry *i)
 {
+	/* Skip production if cargo slot is invalid. */
+	if (!IsValidCargoID(i->produced[0].cargo)) return;
+
 	/* We only want to cut trees if all tiles are completed. */
 	for (TileIndex tile_cur : i->location) {
 		if (i->TileBelongsToIndustry(tile_cur)) {
@@ -1160,6 +1163,7 @@ static void ProduceIndustryGoods(Industr
 
 		IndustryBehaviour indbehav = indsp->behaviour;
 		for (auto &p : i->produced) {
+			if (!IsValidCargoID(p.cargo)) continue;
 			p.waiting = ClampTo<uint16_t>(p.waiting + p.rate);
 		}
 
diff --git a/src/newgrf_industries.cpp b/src/newgrf_industries.cpp
--- a/src/newgrf_industries.cpp
+++ b/src/newgrf_industries.cpp
@@ -643,9 +643,11 @@ void IndustryProductionCallback(Industry
 		if (group->version < 2) {
 			/* Callback parameters map directly to industry cargo slot indices */
 			for (uint i = 0; i < group->num_input; i++) {
+				if (!IsValidCargoID(ind->accepted[i].cargo)) continue;
 				ind->accepted[i].waiting = ClampTo<uint16_t>(ind->accepted[i].waiting - DerefIndProd(group->subtract_input[i], deref) * multiplier);
 			}
 			for (uint i = 0; i < group->num_output; i++) {
+				if (!IsValidCargoID(ind->produced[i].cargo)) continue;
 				ind->produced[i].waiting = ClampTo<uint16_t>(ind->produced[i].waiting + std::max(DerefIndProd(group->add_output[i], deref), 0) * multiplier);
 			}
 		} else {